Tizanidine

  • #LGM Pharma is a Tizanidine CAS# 51322-75-9 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 51322-75-9
  • AHFC code: 12:20.0
  • Synonyms: Tizanidina [INN-Spanish] Tizanidine Hcl Tizanidinum [INN-Latin]
  • ATC Code: M03BX02
  • Chemical Formula: C11H16N2O
  • Molecular Weight: 253.711
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00697 (APRD00128)
  • SMILES: ClC1=C(NC2=NCCN2)C2=NSN=C2C=C1
  • InChl: XFYDIVBRZNQMJC-UHFFFAOYSA-N
  • PubChem: 5487
  • IUPAC: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine

Additional Details

Indication:
For the management of increased muscle tone associated with spasticity
Pharmacodynamics:
Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.
Mode of Action:
Tizanidine reduces spasticity by increasing presynaptic inhibition of motor neurons through agonist action at a2-adrenergic receptor sites.
Metabolism:
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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