Tenoxicam

CAS No:
59804-37-4 Category:
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Product Details:

  • CAS No: 59804-37-4
  • AHFC code: 28:08.04.92
  • Synonyms: Tenoxicamum [INN-Latin]
  • ATC Code: M01AC02
  • Chemical Formula: C26H31Cl2N5O3
  • Molecular Weight: 337.374
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00469 (APRD00011)
  • SMILES: CN1C(=C(/O)NC2=CC=CC=N2)C(=O)C2=C(C=CS2)S1(=O)=O
  • InChl: WZWYJBNHTWCXIM-RAXLEYEMSA-N
  • PubChem: 5282194
  • IUPAC: (3Z)-3-{hydroxy[(pyridin-2-yl)amino]methylidene}-2-methyl-2H,3H,4H-1$l^{6},5,2-thieno[2,3-e][1$l^{6},2]thiazine-1,1,4-trione

Additional Details

Indication:
For the treatment of rheumatoid arthritis, osteoarthritis, backache, and pain.
Pharmacodynamics:
Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
Mode of Action:
The antiinflammatory effects of tenoxicam may result from the inhibition of the enzyme cycooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.
Metabolism:
Tenoxicam is metabolized in the liver to several pharmacologically inactive metabolites (mainly 5'-hydroxy-tenoxicam).
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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