• #LGM Pharma is a Teniposide CAS# 29767-20-2 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 29767-20-2
  • AHFC code: 10:00.0
  • Synonyms: Teniposido [INN-Spanish] Teniposidum [INN-Latin]
  • ATC Code: L01CB02
  • Chemical Formula: C19H25N5O4
  • Molecular Weight: 656.654
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00444 (APRD00649)
  • SMILES: COC1=CC(=CC(OC)=C1O)[C,H]1[C,,H]2[C,H](COC2=O)[C,H](O[C,,H]2O[C,,H]3COC(O[C,H]3[C,H](O)[C,H]2O)C2=CC=CS2)C2=CC3=C(OCO3)C=C12
  • PubChem: 34698
  • IUPAC: (10R,11R,15R,16S)-16-{[(4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one

Additional Details

Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia
Teniposide is a phase-specific cytotoxic drug, acting in the late S or early G 2 phase of the cell cycle, thus preventing cells from entering mitosis. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA: protein cross-links.
Mode of Action:
The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Teniposide binds to and inhibits DNA topoisomerase II. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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