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Tamsulosin Hydrochloride

CAS No:
106463-17-6 Categories: ,
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Product Details:

  • CAS No:
  • AHFC code:
  • Synonyms: (-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide monohydrochloride, (-)-LY 253352, Alna, Amsulosin hydrochloride, Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, monohydrochloride, (R)-, Expros, Flomax, Josir, LY253351, Omic, Omix, Omnic, Pradif, R-(-)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochloride, R-(-)-YM-12617, RTECS DA4522000, Secotex, Tamsulosin HCl, Tamsulosin hydrochloride, UNII-11SV1951MR, Urolosin, YM-12617-1, YM617
  • ATC Code: G04CA02, G04CA53, G04CA52
  • Chemical Formula: C20-H28-N2-O5-S.Cl-H
  • Molecular Weight:
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00706 (APRD00036)
  • SMILES: c1(c(ccc(c1)C[C@H](NCCOc1c(cccc1)OCC)C)OC)S(N)(=O)=O.Cl
  • InChl: 1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1
  • PubChem:
  • IUPAC: Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, monohydrochloride, (R)-

Additional Details

Indication:
Pharmacodynamics:
Tamsulosin, a sulfamoylphenethylamine-derivative alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH). The drug is commercially available in a racemic mixture of 2 isomers, and is pharmacologically related to doxazocin, prazosin, and terazosin. However, unlike these drugs, tamsulosin has a higher affinity for the alpha-1A- adrenergic receptors, which are located in vascular smooth muscle. Studies show that tamsulosin has about 12 times greater affinity for alpha-1 adrenergic receptors in the prostate than those in the aorta, which may result in a reduced incidence of adverse cardiovascular effects.
Mode of Action:
Metabolism:
Tamsulosin HCI is extensively metabolized by cytochrome P450 enzymes in the liver, however, the pharmacokinetic profile of the metabolites in humans has not been established.
Toxicity:
LD50 = 650 mg/kg (in rats)
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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