72-14-0 Category:
  • #LGM Pharma is a Sulfathiazole CAS# 72-14-0 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 72-14-0
  • AHFC code:
  • Synonyms: 2-(P-Aminobenzenesulfonamido)thiazole, 2-(P-Aminobenzenesulphonamido)thiazole, 2-(Sulfanilylamino)thiazole, 2-Sulfanilamidothiazol, 2-Sulfanilamidothiazole, 2-Sulfonamidothiazole, 4-Amino-N-2-thiazolylbenzenesulfonamide, N(1)-2-Thiazolylsulfanilamide, N1-2-Thiazolylsulfanilamide, Sulfanilamidothiazole
  • ATC Code: D06BA02" J01EB07
  • Chemical Formula: C9H9N3O2S2
  • Molecular Weight: 255.317
  • Assay/Purity: Typically NLT 98%
  • DrugBank:
  • SMILES: NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CS1
  • InChl: InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
  • PubChem:
  • IUPAC: 4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide

Additional Details

Sulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle.
Mode of Action:
Metabolism of sulfonamide drugs in animals includes conjugation at the N4-position (acetyl, sulfate, glucuronic acid, and glucose), conjugation at the N1-position (sulfate and glucuronic acid), removal of the p-amino group (formation of the desamino metabolite), ring hydroxylation, and conjugation of the ring hydroxylation products. Dietary nitrite enhances the production of the desamino metabolite of sulfathiazole. The intermediate leading to the desamino metabolite of sulfamethazine is weakly mutagenic in the Ames test (Nelson et al., 1987; Paulson et al., 1987).
Acute oral toxicity (LD50): 4500 mg/kg [Mouse].
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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