• #LGM Pharma is a Simvastatin CAS# 79902-63-9 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 79902-63-9
  • AHFC code: 24:06.1
  • Synonyms: Simvastatin [Usan:Ban:Inn] Simvastatina [Spanish] Simvastatine [French] Simvastatinum [Latin]
  • ATC Code: C10AA01
  • Chemical Formula: C22H30N2O5S2
  • Molecular Weight: 418.5662
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00641 (APRD00104)
  • SMILES: [H][C,]12[C,H](C[C,,H](C)C=C1C=C[C,H](C)[C,,H]2CC[C,,H]1C[C,,H](O)CC(=O)O1)OC(=O)C(C)(C)CC
  • PubChem: 54454
  • IUPAC: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate

Additional Details

For the treatment of hypercholesterolemia.
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Mode of Action:
The 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.
Hepatic, simvastatin is a substrate for CYP3A4.
General Reference:
Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE: Simvastatin is associated with a reduced incidence of dementia and Parkinsonês disease. BMC Med. 2007 Jul 19;5:20. Pubmed
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