Simeprevir Sodium

CAS No:
1241946-89-3 Categories: , ,
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Product Details:

  • CAS No: 1241946-89-3
  • AHFC code:
  • Synonyms:
  • ATC Code: J05AE14
  • Chemical Formula:
  • Molecular Weight:
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB06290
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC:

Additional Details

Indication:
Simeprevir is indicated in patient's with hepatitis C virus (HCV) genotype 1 for the treatment of chronic hepatitis as a combination therapy, which includes peginterferon alfa and ribavirin.
Pharmacodynamics:
Simeprevir is a protease inhibitor for HCV NS3/4A protease, which is required for replication of the virus.
Mode of Action:
Simeprevir functions as a direct-acting antiviral agent because it inhibits hepatitis C viral replication by binding to and inhibiting the protease, hepatitis C virus (HCV) NS3/4A.
Metabolism:
Simeprevir is mainly metabolized by CYP3A enzymes.
Toxicity:
In patients receiving the combination therapy, the most common adverse reactions were nausea, pruritus, photosensitivity, and rash.
General Reference:
Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24. PubmedFDA label.
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