Saquinavir

CAS No:
127779-20-8 Category:
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Product Details:

  • CAS No: 127779-20-8
  • AHFC code: 08:18.08.08
  • Synonyms: Saquinavir Mesylate SQV
  • ATC Code: J05AE01
  • Chemical Formula: C20H15Cl3N2OS
  • Molecular Weight: 670.8408
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01232 (APRD00623)
  • SMILES: CC(C)(C)NC(=O)[C,,H]1CC2CCCCC2CN1C[C,,H](O)[C,H](CC1=CC=CC=C1)NC(=O)[C,H](CC(N)=O)NC(=O)C1=NC2=CC=CC=C2C=C1
  • InChl: QWAXKHKRTORLEM-LINFGICFSA-N
  • PubChem: 60787
  • IUPAC: (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-decahydroisoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinolin-2-ylformamido)butanediamide

Additional Details

Indication:
For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
Pharmacodynamics:
Saquinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Saquinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Mode of Action:
Saquinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Metabolism:
Hepatic
Toxicity:
Probably experience pain in the throat
General Reference:
Forestier F, de Renty P, Peytavin G, Dohin E, Farinotti R, Mandelbrot L: Maternal-fetal transfer of saquinavir studied in the ex vivo placental perfusion model. Am J Obstet Gynecol. 2001 Jul;185(1):178-81. Pubmed
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