• #LGM Pharma is a Rituximab CAS# 174722-31-7 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 174722-31-7
  • AHFC code: 10:00.0
  • Synonyms: HSDB 7455, IDEC-102, IDEC-C2B8, Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer, Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer. Molecular weight is approximately 144,187 daltons, Mab Thera, MabThera, PF 05280586, PF-05280586, Rituxan, Rituximab, UNII-4F4X42SYQ6
  • ATC Code: L01XC02
  • Chemical Formula: C6416-H9874-N1688-O1987-S44
  • Molecular Weight: 143859.7 Da
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00073
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC: Immunoglobulin G1, anti-(human CD20 (antigen)(human-mouse monoclonal IDEC-C2B8 gamma1-chain), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer

Additional Details

Indication:
For treatment of CD20-positive non-Hodgkins lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis.
Pharmacodynamics:
Rituximab binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin’s lympohomas. The antibody leads to selective killing of B-cells.
Mode of Action:
The Fab regions of rituximab binds to the CD20 antigen on B lymphocytes, while the Fc domain recruits antibodies and complements to mediate cell lysis.
Metabolism:
Most likely removed by opsonization via the reticuloendothelial system when bound to B lymphocytes, or by human antimurine antibody production
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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