Reteplase

CAS No:
133652-38-7 Categories: , ,
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Product Details:

  • CAS No: 133652-38-7
  • AHFC code:
  • Synonyms: t- PA t-plasminogen activator Tissue-type plasminogen activator precursor tPA
  • ATC Code: B01AD07
  • Chemical Formula: C12H21N
  • Molecular Weight: 39589.6
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00015 (BIOD00013, BTD00013)
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC:

Additional Details

Indication:
For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction
Pharmacodynamics:
Reteplase cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.
Mode of Action:
Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.
Metabolism:
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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