Reserpine

CAS No:
50-55-5 Category:
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 50-55-5
  • AHFC code:
  • Synonyms:
  • ATC Code: C02AA02
  • Chemical Formula: C8H5F3N2OS
  • Molecular Weight: 608.6787
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00206 (APRD00472)
  • SMILES: CO[C,H]1[C,,H](C[C,,H]2CN3CCC4=C(NC5=C4C=CC(OC)=C5)[C,H]3C[C,,H]2[C,,H]1C(=O)OC)OC(=O)C1=CC(OC)=C(OC)C(OC)=C1
  • InChl: QEVHRUUCFGRFIF-MDEJGZGSSA-N
  • PubChem: 5770
  • IUPAC: methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-[(3,4,5-trimethoxyphenyl)carbonyloxy]-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylate

Additional Details

Indication:
Foe the treatment of hypertension
Pharmacodynamics:
Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Reserpine are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral resistance.
Mode of Action:
Reserpine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.
Metabolism:
Toxicity:
Possible human carcinogen. May cause reproductive harm. ORL-RAT LD50 420 mg/kg; IPR-RAT LD50 44 mg/kg; IVN-RAT LD50 15 mg/kg; ORL-MUS LD50 200 mg/kg; SCU-MUS LD50 52 mg/kg; IPR-RBT LD50 7 mg/kg
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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