Remifentanil

CAS No:
132875-61-7 Categories: , ,
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Product Details:

  • CAS No: 132875-61-7
  • AHFC code: 28:08.1
  • Synonyms: GI 87084X, Remifentanil, Remifentanyl, UNII-P10582JYYK
  • ATC Code: N01AH06
  • Chemical Formula: C20-H28-N2-O5
  • Molecular Weight: 376.4502
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00899
  • SMILES: CCC(=O)N(c1ccccc1)C2(CCN(CC2)CCC(=O)OC)C(=O)OC
  • InChl: 1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3
  • PubChem:
  • IUPAC: 1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester

Additional Details

Indication:
For use during the induction and maintenance of general anesthesia.
Pharmacodynamics:
Remifentanil is an opioid agonist with rapid onset and peak effect and ultra-short duration of action. The opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone. The analgesic effects of remifentanil are rapid in onset and offset. Its effects and side effects are dose dependent and similar to other opioids. Remifentanil in humans has a rapid blood-brain equilibration half-time of 1 ± 1 minutes (mean ± SD) and a rapid onset of action.
Mode of Action:
Remifentanil is a µ-opioid agonist with rapid onset and peak effect, and short duration of action. The µ-opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone.
Metabolism:
By hydrolysis of the propanoic acid-methyl ester linkage by nonspecific blood and tissue esterases.
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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