• #LGM Pharma is a Prucalopride CAS# 179474-81-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 179474-81-8
  • AHFC code:
  • Synonyms: 4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancarboxamide, Prucalopride, UNII-0A09IUW5TP
  • ATC Code: A06AX05
  • Chemical Formula: C18-H26-Cl-N3-O3
  • Molecular Weight: 367.8744
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB06480
  • SMILES: COCCCN1CCC(CC1)NC(=O)c2cc(c(c3c2OCC3)N)Cl
  • InChl: 1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
  • PubChem:
  • IUPAC: 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide

Additional Details

Investigated for use/treatment in constipation, ileus, and pediatric indications.
Mode of Action:
Prucalopride (PRU) is a selective high affinity 5-HT4 agonist, which are involved in initiating peristalsis. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation.
In vitro, human liver metabolism is very slow and only minor amounts of metabolites are found.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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