• #LGM Pharma is a Probucol CAS# 23288-49-5 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 23288-49-5
  • AHFC code: 24:06.9
  • Synonyms: 4,4'- (Isopropylidenedithio)bis(2, 6-di-tert-butylphenol) 4,4'-(Isopropylidenedithio)bis(2, 6-di-tert-butylphenol) 4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol) 4,4'-(Isopropylidenedithio)bis[2, 6-di-tert-butylphenol] Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole Acetone, bis (3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole Probucolum [inn-latin]
  • ATC Code: C10AX02
  • Chemical Formula: C21H30O2
  • Molecular Weight: 516.842
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01599
  • SMILES: CC(C)(SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C
  • PubChem: 4912
  • IUPAC: 2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol

Additional Details

Used to lower LDL and HDL cholesterol.
Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant drug normally used to prevent vascular disease caused by the free radicals in the body.
Mode of Action:
Probucol lowers serum cholesterol by increasing the fractional rate of low-density lipoprotein (LDL) catabolism in the final metabolic pathway for cholesterol elimination from the body. Additionally, probucol may inhibit early stages of cholesterol biosynthesis and slightly inhibit dietary cholesterol absorption. Recent information suggests that probucol may inhibit the oxidation and tissue deposition of LDL cholesterol, thereby inhibiting atherogenesis. It appears to inhibits ABCA1-mediated cellular lipid efflux.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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