Prilocaine

CAS No:
721-50-6 Category:
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 721-50-6
  • AHFC code: 12:00.0
  • Synonyms:
  • ATC Code: N01BB04
  • Chemical Formula: C16H22N2O3
  • Molecular Weight: 220.3107
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00750 (APRD00180)
  • SMILES: CCCNC(C)C(=O)NC1=CC=CC=C1C
  • InChl: MVFGUOIZUNYYSO-UHFFFAOYSA-N
  • PubChem: 4906
  • IUPAC: N-(2-methylphenyl)-2-(propylamino)propanamide

Additional Details

Indication:
Used as a local anaesthetic and is often used in dentistry.
Pharmacodynamics:
Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.
Mode of Action:
Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Metabolism:
Toxicity:
General Reference:
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