153168-05-9 Category:
  • #LGM Pharma is a Pleconaril CAS# 153168-05-9 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 153168-05-9
  • AHFC code:
  • Synonyms: 3-(3,5-Dimethyl-4-(3-(3-methyl-5-isoxazolyl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole, 3-(4-(3-(3-Methyl-5-isoxazolyl)propoxy)-3,5-xylyl)-5-trifluoromethyl)-1,2,4-oxadizole, Picovir, Pleconaril, UNII-9H4570Q89D, VP 63843, VP-63843, Win 63843, Win-63843
  • ATC Code: J05AX06
  • Chemical Formula: C18-H18-F3-N3-O3
  • Molecular Weight: 381.352
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB05105
  • SMILES: n1c(onc1c1cc(c(OCCCc2cc(no2)C)c(c1)C)C)C(F)(F)F
  • InChl: 1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
  • PubChem: 1684
  • IUPAC: 1,2,4-Oxadiazole, 3-(3,5-dimethyl-4-(3-(3-methyl-5-isoxazolyl)propoxy)phenyl)-5-(trifluoromethyl)-

Additional Details

Investigated for use/treatment in upper respiratory infection.
Mode of Action:
Pleconaril binds to a hydrophobic pocket in viral protein 1, the major protein which comprises the capsid (the outer "shell") of picornaviruses. In enteroviruses, this prevents the virus from exposing its RNA, and in rhinoviruses it also prevents the virus from attaching itself to the host cell.
General Reference:
Webster AD: Pleconaril—an advance in the treatment of enteroviral infection in immuno-compromised patients. J Clin Virol. 2005 Jan;32(1):1-6. PubmedFlorea NR, Maglio D, Nicolau DP: Pleconaril, a novel antipicornaviral agent. Pharmacotherapy. 2003 Mar;23(3):339-48. Pubmed
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