Pipobroman

CAS No:
54-91-1 Category:
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Product Details:

  • CAS No: 54-91-1
  • AHFC code:
  • Synonyms:
  • ATC Code: L01AX02
  • Chemical Formula: C171H267N51O53S2
  • Molecular Weight: 356.054
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00236 (APRD00693)
  • SMILES: BrCCC(=O)N1CCN(CC1)C(=O)CCBr
  • InChl: NJBFOOCLYDNZJN-UHFFFAOYSA-N
  • PubChem: 4842
  • IUPAC: 3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one

Additional Details

Indication:
For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.
Pharmacodynamics:
Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.
Mode of Action:
The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death.
Metabolism:
Toxicity:
Symptoms of overdose include hematologic toxicity, especially with chronic overdosage.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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