Phenylbutazone

CAS No:
50-33-9 Category:
  • #LGM Pharma is a Phenylbutazone CAS# 50-33-9 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 50-33-9
  • AHFC code: 28:08.04.92
  • Synonyms:
  • ATC Code: M01AA01 M02AA01
  • Chemical Formula: C19H20N2O3S
  • Molecular Weight: 308.3743
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00812 (APRD00409, DB08343)
  • SMILES: CCCCC1C(=O)N(N(C1=O)C1=CC=CC=C1)C1=CC=CC=C1
  • InChl: VYMDGNCVAMGZFE-UHFFFAOYSA-N
  • PubChem: 4781
  • IUPAC: 4-butyl-1,2-diphenylpyrazolidine-3,5-dione

Additional Details

Indication:
For the treatment of backache and ankylosing spondylitis
Pharmacodynamics:
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Mode of Action:
Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.
Metabolism:
Toxicity:
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Cost effective materials based on specific requirements
  • Small quantities for initial research and larger development quantities towards product commercialization

 

  • Technical packages, letters of access to filed DMFs
  • Complete assistance in any regulatory filings
  • Top quality GMP certified manufacturers
  • Have necessary regulatory credentials

 

Related YouTube Videos