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Perampanel

  • #LGM Pharma is a Perampanel CAS# 380917-97-5 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 380917-97-5
  • AHFC code:
  • Synonyms: E-2007
  • ATC Code: N03AX22
  • Chemical Formula:
  • Molecular Weight:
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB08883
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC:

Additional Details

Indication:
Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.
Pharmacodynamics:
Perampanel is involved in inhibiting neuronal excitation in the central nervous system leading to such effects as decreased pyschomotor performance.
Mode of Action:
The exact mechanism of action of perampanel in seizures is not yet determined, but it is known that perampanel decreases neuronal excitation by non-competitive ihibition of the AMPA receptor.
Metabolism:
Perampanel is highly metabolized by CYP3A4 and/or CYP3A5 primary oxidation and by sequential glucuronidation.
Toxicity:
The FDA label includes an important warning of serious or life-threatening behavioral and psychiatric adverse reactions including aggression, hostility, irritability, anger, and homicidal thoughts in patients taking perampanel.
General Reference:
Hanada T, Hashizume Y, Tokuhara N, Takenaka O, Kohmura N, Ogasawara A, Hatakeyama S, Ohgoh M, Ueno M, Nishizawa Y: Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia. 2011 Jul;52(7):1331-40. doi: 10.1111/j.1528-1167.2011.03109._. Epub 2011 Jun 2. Pubmed FDA label.
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