Pentoxifylline

CAS No:
6493-05-6 Category:
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Product Details:

  • CAS No: 6493-05-6
  • AHFC code: 20:24.0
  • Synonyms: EHT0201
  • ATC Code: C04AD03
  • Chemical Formula: C18H16O3
  • Molecular Weight: 278.307
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00806 (APRD00121)
  • SMILES: CN1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C
  • InChl: BYPFEZZEUUWMEJ-UHFFFAOYSA-N
  • PubChem: 4740
  • IUPAC: 3,7-dimethyl-1-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione

Additional Details

Indication:
For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.
Pharmacodynamics:
Pentoxifylline, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Mode of Action:
Pentoxifylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, pentoxifylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. It is also a non selective adenosine receptor antagonist.
Metabolism:
Toxicity:
LD50=1385 mg/kg(orally in mice)
General Reference:
: European Pentoxifylline Multi-Infarct Dementia Study. Eur Neurol. 1996;36(5):315-21. Pubmed
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