Penciclovir

  • #LGM Pharma is a Penciclovir CAS# 39809-25-1 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 39809-25-1
  • AHFC code: 24:04.1
  • Synonyms: PE2 Penciclovirum [INN-Latin]
  • ATC Code: D06BB06 J05AB13
  • Chemical Formula: C19H26N2S
  • Molecular Weight: 253.2578
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00299 (APRD00041, DB01730)
  • SMILES: NC1=NC(=O)C2=C(N1)N(CCC(CO)CO)C=N2
  • InChl: JNTOCHDNEULJHD-UHFFFAOYSA-N
  • PubChem: 4725
  • IUPAC: 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6,9-dihydro-3H-purin-6-one

Additional Details

Indication:
Used to treat recurrent cold sores on the lips and face from various herpesvirus invections.
Pharmacodynamics:
Penciclovir is the active metabolite of the oral product famciclovir. The more favorable results observed with topical penciclovir versus topical acyclovir for the treatment of herpes labialis may be due to the longer intracellular half-life of penciclovir in HSV-infected cells. The activated drug inhibits the viral DNA polymerase. This impairs the ability of the virus to replicate within the cell.
Mode of Action:
Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of penciclovir is retained in vitro inside HSV-infected cells for 10-20 hours, compared with 0.7-1 hour for acyclovir. in vitro studies show that penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. Inhibition of DNA synthesis of virus-infected cells inhibits viral replication. In cells not infected with HSV, DNA synthesis is unaltered. Resistant mutants of HSV can occur from qualitative changes in viral thymidine kinase or DNA polymerase. The most commonly encountered acyclovir-resistant mutants that are deficient in viral thymidine kinase are also resistant to penciclovir.
Metabolism:
Hepatic
Toxicity:
Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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