Pegaptanib Octasodium

CAS No:
250689-71-5 Category:
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Product Details:

  • CAS No: 250689-71-5
  • AHFC code:
  • Synonyms: EYE 001,NX 1838, Pegaptanib Octasodium, Pegaptanib sodium
  • ATC Code: S01LA03
  • Chemical Formula: C294H342F13N107Na28O188P28[C2H4O]2n
  • Molecular Weight: 535.5031
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB04895
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC:

Additional Details

Indication:
Pegaptanib is indicated for the treatment of endovascular/wet age-related macular degeneration and diabetic macular edema.
Pharmacodynamics:
As a polynucleotide aptamer Pegaptanib binds specifically to VEGF 165, which is the protein that elicits angiogenesis (and increases permeability.
Mode of Action:
Pegaptanib is a modified oligonucleotide that binds to the major pathological VEGF isoform, extracellular VEGF165, with a high affinity.
Metabolism:
In animal studies Pegaptanib slowly absorbs into the body via an intravenous injection into the eye. Clinical data shows that Pegaptanib is metabolized by both the endo- and exonucleases.
Toxicity:
Pegaptanib has not been studied for toxicity in pregnant women or the pediatric population. The majority of adverse effects related to Pegaptanib are and minor. A small number of patients report non-ocular events, such as headache when the procedure occurs, but this is uncommon. Pegaptanib should not be used if the patient has a periocular or ocular infection.
General Reference:
Expert Opinion on Drug Metabolism &amp Toxicology (Impact Factor: 2.93). 05/2014; DOI: 10.1517/17425255.2014.922543Clinical ophthalmology (Auckland, N.Z.) 02/2015; 9:323-35. DOI:10.2147/OPTH.S74050Acta Ophthalmologica .4 JAN 2015. DOI: 10.1111/aos.12603.
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