Oxaprozin

CAS No:
21256-18-8 Category:
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Product Details:

  • CAS No: 21256-18-8
  • AHFC code: 28:08.04.92
  • Synonyms: Oxaprozina [INN-Spanish] Oxaprozine [INN-French] Oxaprozinum [INN-Latin]
  • ATC Code: M01AE12
  • Chemical Formula: C22H31NO3
  • Molecular Weight: 293.3166
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00991 (APRD00030)
  • SMILES: OC(=O)CCC1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1
  • InChl: OFPXSFXSNFPTHF-UHFFFAOYSA-N
  • PubChem: 4614
  • IUPAC: 3-(diphenyl-1,3-oxazol-2-yl)propanoic acid

Additional Details

Indication:
Used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis.
Pharmacodynamics:
Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.
Mode of Action:
Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin is a non-selective NSAID, with a cell assay system showing lower COX-2 selectivity implying higher COX-1 selectivity.
Metabolism:
Hepatic. Ester and ether glucuronide are the major conjugated metabolites of oxaprozin, and do not have significant pharmacologic activity.
Toxicity:
Oral, mouse: LD50 = 1210 mg/kg; Oral, rabbit: LD50 = 172 mg/kg; Oral, rat: LD50 = 4470 mg/kg
General Reference:
Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90. Pubmed
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