• #LGM Pharma is a Omalizumab CAS# 242138-07-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 242138-07-4
  • AHFC code: 49:32.0
  • Synonyms:
  • ATC Code: R03DX05
  • Chemical Formula: C6450H9916N1714O2023S38
  • Molecular Weight: 145058.2 Da
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00043
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC:

Additional Details

Indication:
For treatment of asthma caused by allergies
Pharmacodynamics:
Xolair inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Xolair is used to treat severe, persisten asthma.
Mode of Action:
Xolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
Metabolism:
Most likely removed by opsonization via the reticuloendothelial system.
Toxicity:
General Reference:
Karagiannis SN, Wang Q, East N, Burke F, Riffard S, Bracher MG, Thompson RG, Durham SR, Schwartz LB, Balkwill FR, Gould HJ: Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells. Eur J Immunol. 2003 Apr;33(4):1030-40. Pubmed
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