LGM Pharma is a Omalizumab CAS# 242138-07-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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LGM Pharma offers this active ingredient but not the finished dosage forms.
CAS No: 242138-07-4
AHFC code: 49:32.0
ATC Code: R03DX05
Chemical Formula: C6450H9916N1714O2023S38
Molecular Weight: 145058.2 Da
Assay/Purity: Typically NLT 98%
For treatment of asthma caused by allergies
Xolair inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Xolair is used to treat severe, persisten asthma.
Mode of Action:
Xolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
Most likely removed by opsonization via the reticuloendothelial system.
Karagiannis SN, Wang Q, East N, Burke F, Riffard S, Bracher MG, Thompson RG, Durham SR, Schwartz LB, Balkwill FR, Gould HJ: Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells. Eur J Immunol. 2003 Apr;33(4):1030-40. Pubmed
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