• #LGM Pharma is a Octreotide CAS# 83150-76-9 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 83150-76-9
  • AHFC code: 32:00.0
  • Synonyms: Octreotida [Spanish] Octreotidum [Latin] Octrotide
  • ATC Code: H01CB02
  • Chemical Formula: C18H19N3O
  • Molecular Weight: 1019.239
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00104 (BIOD00088, BTD00088)
  • SMILES: C[C,,H](O)[C,,H](CO)NC(=O)[C,,H]1CSSC[C,H](NC(=O)[C,H](N)CC2=CC=CC=C2)C(=O)N[C,,H](CC2=CC=CC=C2)C(=O)N[C,H](CC2=CNC3=C2C=CC=C3)C(=O)N[C,,H](CCCCN)C(=O)N[C,,H](C(C)O)C(=O)N1
  • InChl: DEQANNDTNATYII-RRCPSWKPSA-N
  • PubChem: 54373
  • IUPAC: (4R,7S,10S,13R,16S,19R)-19-[(2R)-2-amino-3-phenylpropanamido]-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide

Additional Details

Indication:
For treatment of acromegaly and reduction of side effects from cancer chemotherapy
Pharmacodynamics:
Octreotide exerts pharmacologic actions similar to the natural hormone, somatostatin. It is an even more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Like somatostatin, it also suppresses leuteinizing hormone (LH) response to GnRH, decreases splanchnic blood flow, and inhibits release of serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, and pancreatic polypeptide. Octreotide has been used to treat the symptoms associated with metastatic carcinoid tumors (flushing and diarrhea), and Vasoactive Intestinal Peptide (VIP) secreting adenomas (watery diarrhea). Octreotide substantially reduces and in many cases can normalize growth hormone and/or IGF-1 (somatomedin C) levels in patients with acromegaly.
Mode of Action:
Octreotide binds to somatostatin receptors. These receptors are coupled via pertussis toxin sensitive G proteins which lead to inhibition of adenylyl cyclase. Octreotide binding to these receptors also stimulates phosphotyrosine phosphatase and activation of the Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
Metabolism:
Toxicity:
General Reference:
Uhl W, Anghelacopoulos SE, Friess H, Buchler MW: The role of octreotide and somatostatin in acute and chronic pancreatitis. Digestion. 1999;60 Suppl 2:23-31. Pubmed
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