Nortriptyline

CAS No:
72-69-5 Category:
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Product Details:

  • CAS No: 72-69-5
  • AHFC code: 28:16.04.28
  • Synonyms:
  • ATC Code: N06AA10
  • Chemical Formula: C21H23NO3
  • Molecular Weight: 263.3767
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00540 (APRD00602)
  • SMILES: CNCCC=C1C2=CC=CC=C2CCC2=CC=CC=C12
  • InChl: PHVGLTMQBUFIQQ-UHFFFAOYSA-N
  • PubChem: 4543
  • IUPAC: methyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine

Additional Details

Indication:
For the treatment of depression, chronic pain, irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation and insomnia, and migraine prophylaxis.
Pharmacodynamics:
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline.
Mode of Action:
It is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at beta-adrenergic receptors. Tricyclic antidepressants do not inhibit monoamine oxidase nor do they affect dopamine reuptake.
Metabolism:
Undergoes hepatic metabolism via the same pathway as other TCAs.
Toxicity:
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.
General Reference:
Prochazka AV, Weaver MJ, Keller RT, Fryer GE, Licari PA, Lofaso D: A randomized trial of nortriptyline for smoking cessation. Arch Intern Med. 1998 Oct 12;158(18):2035-9. Pubmed
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