51803-78-2 Category:
  • #LGM Pharma is a Nimesulide CAS# 51803-78-2 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 51803-78-2
  • AHFC code:
  • Synonyms:
  • ATC Code: M01AX17 M02AA26
  • Chemical Formula: C18H20N2O6
  • Molecular Weight: 308.31
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB04743
  • SMILES: CS(=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O
  • PubChem:
  • IUPAC: N-(4-nitro-2-phenoxyphenyl)methanesulfonamide

Additional Details

For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.
Mode of Action:
The therapeutic effects of Nimesulide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Hepatic. Extensive biotransformation, mainly to 4-hydroxynimesulide (which also appears to be biologically active).
Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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