Nimesulide

CAS No:
51803-78-2 Category:
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Product Details:

  • CAS No: 51803-78-2
  • AHFC code:
  • Synonyms:
  • ATC Code: M01AX17 M02AA26
  • Chemical Formula: C18H20N2O6
  • Molecular Weight: 308.31
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB04743
  • SMILES: CS(=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O
  • InChl: HYWYRSMBCFDLJT-UHFFFAOYSA-N
  • PubChem:
  • IUPAC: N-(4-nitro-2-phenoxyphenyl)methanesulfonamide

Additional Details

Indication:
For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
Pharmacodynamics:
Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.
Mode of Action:
The therapeutic effects of Nimesulide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Metabolism:
Hepatic. Extensive biotransformation, mainly to 4-hydroxynimesulide (which also appears to be biologically active).
Toxicity:
Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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