• #LGM Pharma is a Nicergoline CAS# 27848-84-6 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 27848-84-6
  • AHFC code:
  • Synonyms:
  • ATC Code: C04AE02
  • Chemical Formula: C19H19N3O6
  • Molecular Weight: 484.386
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00699 (APRD00617)
  • SMILES: CO[C,]12C[C,,H](COC(=O)C3=CC(Br)=CN=C3)CN(C)[C,,H]1CC1=CN(C)C3=CC=CC2=C13
  • PubChem: 34040
  • IUPAC: [(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate

Additional Details

For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
Nicergoline is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergoline also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.
Mode of Action:
Nicergoline acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Nicergoline is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.
General Reference:
Winblad B, Fioravanti M, Dolezal T, Logina I, Milanov IG, Popescu DC, Solomon A: Therapeutic use of nicergoline. Clin Drug Investig. 2008;28(9):533-52. Pubmed 18666801
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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