• #LGM Pharma is a Mupirocin CAS# 12650-69-0 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 12650-69-0
  • AHFC code: 24:04.0
  • Synonyms: MRC Mupirocine Pseudomonic acid
  • ATC Code: D06AX09 R01AX06
  • Chemical Formula: C21H21N
  • Molecular Weight: 500.6222
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00410 (APRD00162)
  • SMILES: C[C,H](O)[C,H](C)[C,,H]1O[C,H]1C[C,H]1CO[C,,H](CC(C)=CC(=O)OCCCCCCCCC(O)=O)[C,H](O)[C,,H]1O
  • InChl: MINDHVHHQZYEEK-HBBNESRFSA-N
  • PubChem: 446596
  • IUPAC: 9-{[(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-{[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl}oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic acid

Additional Details

Indication:
For the treatment of Staphylococci nasal carriers.
Pharmacodynamics:
Mupirocin, an antibiotic produced from Pseudomonas fluorescens, is structurally unrelated to any other topical or systemic antibiotics. Mupirocin is used to treat infection caused by Staphylococcus aureus and beta-hemolytic streptococci including Streptococcus pyogenes. This antibiotic has little, if any, potential for cross-resistance with other antibiotics.
Mode of Action:
Mupirocin reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Prevention of this enzymes from functioning properly results in the inhibition of bacterial protein and RNA synthesis.
Metabolism:
Hepatic. Following intravenous or oral administration, mupirocin is rapidly metabolized. The principal metabolite is monic acid, which has no antibacterial activity.
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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