• #LGM Pharma is a Montelukast CAS# 158966-92-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 158966-92-8
  • AHFC code: 48:10.2
  • Synonyms:
  • ATC Code: R03DC03
  • Chemical Formula: C19H27N5O4
  • Molecular Weight: 586.183
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00471 (APRD00434)
  • SMILES: OC(=O)CC1(CC1)CS[C,H](CCC1=CC=CC=C1C(O)(C)C)C1=CC=CC(C=CC2=NC3=C(C=CC(Cl)=C3)C=C2)=C1
  • InChl: UCHDWCPVSPXUMX-TZIWLTJVSA-N
  • PubChem: 60951
  • IUPAC: 2-[1-({[(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl}methyl)cyclopropyl]acetic acid

Additional Details

Indication:
For the treatment of asthma
Pharmacodynamics:
Montelukast, like zafirlukast, is a leukotriene receptor antagonist used as an alternative to anti-inflammatory medications in the management and chronic treatment of asthma and exercise-induced bronchospasm (EIB). Unlike zafirlukast, montelukast does not inhibit CYP2C9 or CYP3A4 and is, therefore, not expected to affect the hepatic clearance of drugs metabolized by these enzymes.
Mode of Action:
Montelukast selectively antagonizes leukotriene D_ (LTD_) at the cysteinyl leukotriene receptor, CysLT_, in the human airway. Montelukast inhibits the actions of LTD_ at the CysLT_ receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
Metabolism:
Hepatic
Toxicity:
Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Cost effective materials based on specific requirements
  • Small quantities for initial research and larger development quantities towards product commercialization

 

  • Technical packages, letters of access to filed DMFs
  • Complete assistance in any regulatory filings
  • Top quality GMP certified manufacturers
  • Have necessary regulatory credentials

 

Related YouTube Videos