Mitoxantrone

CAS No:
65271-80-9 Category:
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Product Details:

  • CAS No: 65271-80-9
  • AHFC code: 10:00.0
  • Synonyms: Mitoxanthrone Mitoxantron
  • ATC Code: L01DB07
  • Chemical Formula: C15H16O2
  • Molecular Weight: 444.4809
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01204 (APRD00371)
  • SMILES: OCCNCCNC1=C2C(=O)C3=C(O)C=CC(O)=C3C(=O)C2=C(NCCNCCO)C=C1
  • InChl: KKZJGLLVHKMTCM-UHFFFAOYSA-N
  • PubChem: 4212
  • IUPAC: 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione

Additional Details

Indication:
For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis
Pharmacodynamics:
Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2.
Mode of Action:
Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.
Metabolism:
Hepatic
Toxicity:
Severe leukopenia with infection.
General Reference:
Fox EJ: Management of worsening multiple sclerosis with mitoxantrone: a review. Clin Ther. 2006 Apr;28(4):461-74. Pubmed
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