• #LGM Pharma is a Mitotane CAS# 53-19-0 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 53-19-0
  • AHFC code: 10:00.0
  • Synonyms:
  • ATC Code: L01XX23
  • Chemical Formula: C26H44O9
  • Molecular Weight: 320.041
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00648 (APRD00494)
  • SMILES: ClC(Cl)C(C1=CC=C(Cl)C=C1)C1=CC=CC=C1Cl
  • InChl: JWBOIMRXGHLCPP-UHFFFAOYSA-N
  • PubChem: 4211
  • IUPAC: 1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene

Additional Details

Indication:
For treatment of inoperable adrenocortical tumours; Cushing's syndrome
Pharmacodynamics:
Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.
Mode of Action:
Its biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.
Metabolism:
Hepatic and renal
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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