• #LGM Pharma is a Mitomycin CAS# 50-07-7 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 50-07-7
  • AHFC code: 10:00.0
  • Synonyms: 7-Amino-9_-methoxymitosane Mitamycin MMC
  • ATC Code: L01DC03
  • Chemical Formula: C35H36ClNO3S
  • Molecular Weight: 334.3272
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00305 (APRD00284)
  • SMILES: CO[C,]12[C,H]3N[C,H]3CN1C1=C([C,H]2COC(N)=O)C(=O)C(N)=C(C)C1=O
  • InChl: NWIBSHFKIJFRCO-WUDYKRTCSA-N
  • PubChem: 5746
  • IUPAC: [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.0^{2,7}.0^{4,6}]trideca-1(9),11-dien-8-yl]methyl carbamate

Additional Details

Indication:
For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery.
Pharmacodynamics:
Mitomycin is one of the older chemotherapy drugs, which has been around and in use for decades. It is an antibiotic which has been shown to have antitumor activity. Mitomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Mitomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2.
Mode of Action:
Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
Metabolism:
Primarily hepatic, some in various other tissues.
Toxicity:
Oral, mouse: LD50 = 23 mg/kg; Oral, rat: LD50 = 30 mg/kg. Symptoms of overdose include nausea and vomiting.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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