Indicated for the treatment of congestive heart failure.
Milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Mode of Action:
Milrinone inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Milrinone also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.
There are five metabolites but the O-glucuronide represents the major pathway of biotransformation.
LD50 = 0.3 mg/L in rats
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API’s From Quality Manufacturers:
Cost effective materials based on specific requirements
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Technical packages, letters of access to filed DMFs