78415-72-2 Category:
  • #LGM Pharma is a Milrinone CAS# 78415-72-2 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 78415-72-2
  • AHFC code: 24:04.1
  • Synonyms: Milrinone Lactate
  • ATC Code: C01CE02
  • Chemical Formula: C22H28N4O6
  • Molecular Weight: 211.2194
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00235 (APRD00010)
  • SMILES: CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1
  • PubChem: 4197
  • IUPAC: 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile

Additional Details

Indicated for the treatment of congestive heart failure.
Milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Mode of Action:
Milrinone inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Milrinone also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.
There are five metabolites but the O-glucuronide represents the major pathway of biotransformation.
LD50 = 0.3 mg/L in rats
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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