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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 51384-51-1
  • AHFC code:
  • Synonyms: (RS)-Metoprolol, Beatrolol, Betaloc, CCRIS 4198, CGP 2175, Corvitol, dl-Metoprolol, EINECS 257-166-4, HSDB 6531, Loresor, Meijoprolol, Metohexal, Metoprolol, Metoprololum, Metoprololum [INN-Latin], Metrol, Minax, Neobloc, Preblok, Presolol, Selokeen, Seroken, Spesicor, Toprol, UNII-GEB06NHM23
  • ATC Code:
  • Chemical Formula: C15-H25-N-O3
  • Molecular Weight: 267.3665
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00264
  • SMILES: N(CC(COc1ccc(cc1)CCOC)O)C(C)C
  • InChl: 1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
  • PubChem:
  • IUPAC: 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol

Additional Details

Indication:
For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Pharmacodynamics:
Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).
Mode of Action:
Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
Metabolism:
Primarily hepatic
Toxicity:
LD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090 mg/kg (orally in mice)
General Reference:
: Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet. 1999 Jun 12;353(9169):2001-7. Pubmed
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