Methoxsalen

CAS No:
298-81-7 Category:
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Product Details:

  • CAS No: 298-81-7
  • AHFC code: 24:50.1
  • Synonyms: Methoxalen Xanthotoxin Xanthotoxine Xanthoxin Zanthotoxin
  • ATC Code: D05AD02 D05BA02
  • Chemical Formula: C23H36O6
  • Molecular Weight: 216.1895
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00553 (APRD00157)
  • SMILES: COC1=C2OC(=O)C=CC2=CC2=C1OC=C2
  • InChl: QXKHYNVANLEOEG-UHFFFAOYSA-N
  • PubChem: 4114
  • IUPAC: 9-methoxy-2H-furo[3,2-g]chromen-2-one

Additional Details

Indication:
For the treatment of psoriasis and vitiligo
Pharmacodynamics:
Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Mode of Action:
After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Metabolism:
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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