569-65-3 Categories: , , ,
  • #LGM Pharma is a Meclizine CAS# 569-65-3 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 569-65-3
  • AHFC code: 56:22.1
  • Synonyms:
  • ATC Code: R06AE05
  • Chemical Formula: C20H22N2S
  • Molecular Weight: 390.948
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00737 (APRD00354)
  • PubChem: 4034
  • IUPAC: 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine

Additional Details

For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Mode of Action:
Along with its actions as an antagonist at H_-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.
Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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