Meclizine

CAS No:
569-65-3 Categories: , , ,
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Product Details:

  • CAS No: 569-65-3
  • AHFC code: 56:22.1
  • Synonyms:
  • ATC Code: R06AE05
  • Chemical Formula: C20H22N2S
  • Molecular Weight: 390.948
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00737 (APRD00354)
  • SMILES: CC1=CC(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1
  • InChl: OCJYIGYOJCODJL-UHFFFAOYSA-N
  • PubChem: 4034
  • IUPAC: 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine

Additional Details

Indication:
For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Pharmacodynamics:
Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Mode of Action:
Along with its actions as an antagonist at H_-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.
Metabolism:
Hepatic
Toxicity:
Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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