Marimastat

CAS No:
154039-60-8 Category:
  • #LGM Pharma is a Marimastat CAS# 154039-60-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 154039-60-8
  • AHFC code:
  • Synonyms:
  • ATC Code:
  • Chemical Formula: C22H32O3
  • Molecular Weight: 331.4079
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00786 (APRD00559)
  • SMILES: CNC(=O)[C,,H](NC(=O)[C,H](CC(C)C)[C,H](O)C(=O)NO)C(C)(C)C
  • InChl: OCSMOTCMPXTDND-OUAUKWLOSA-N
  • PubChem: 119031
  • IUPAC: (2S,3R)-N-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N',2-dihydroxy-3-(2-methylpropyl)butanediamide

Additional Details

Indication:
For the treatment of various cancers
Pharmacodynamics:
Used in the treatment of cancer, it is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.
Mode of Action:
Marimastat is a broad spectrum matrix metalloprotease inhibitor. It mimics the peptide structure of natural MMP substrates and binds to matrix metalloproteases, thereby preventing the degradation of the basement membrane by these proteases. This antiprotease action prevents the migration of endothelial cells needed to form new blood vessels. Inhibition of MMPs also prevents the entry and exit of tumor cells into existing blood cells, thereby preventing metastasis.
Metabolism:
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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