Lecozotan

CAS No:
434283-16-6 Categories: , ,
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Product Details:

  • CAS No: 434283-16-6
  • AHFC code:
  • Synonyms: 4-Cyano-N-(2R-(4-(2,3-dihydrobenzo(1,4)-dioxin-5-yl)-piperazin-1-yl)-propyl)-N-pyridin-2-yl-benzamide hydrochloride, Lecozotan hydrochloride, SRA-333, UNII-48854OTZ5E
  • ATC Code:
  • Chemical Formula: C28-H29-N5-O3
  • Molecular Weight: 483.5691
  • Assay/Purity: Typically NLT 98%
  • DrugBank:
  • SMILES:
  • InChl: 1S/C28H29N5O3/c1-21(31-13-15-32(16-14-31)24-5-4-6-25-27(24)36-18-17-35-25)20-33(26-7-2-3-12-30-26)28(34)23-10-8-22(19-29)9-11-23/h2-12,21H,13-18,20H2,1H3/t21-/m1/s1
  • PubChem: 11156648
  • IUPAC: 4-Cyano-N-[(2R)-2-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl]propyl]-N-2-pyridinylbenzamide hydrochloride

Additional Details

Indication:
Pharmacodynamics:
Mode of Action:
Lecozotan is a competitive, selective 5-HT1A receptor antagonist[3] which enhances the potassium-stimulated release of acetylcholine and glutamate.
Metabolism:
Toxicity:
General Reference:
H. Spreitzer (August 13, 2008). "Neue Wirkstoffe – Lecozotan". Österreichische Apothekerzeitung (in German) (17/2007): 805.ClinicalTrialsSchlechter, LE; Smith, DL; Rosenzweig-Lipson, S; Sukoff, SJ; Dawson, LA; Marquis, K; Jones, D; Piesla, M; et al. (June 10, 2005). "Lecotozan (SRA-333): A selective serotonin1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and promotes procognitive effects". Journal of Pharmacology and Experimental Therapeutics 314 (3): 1274–89. doi:10.1124/jpet.105.086363. PMID 15951399.Childers, WE Jr, Harrison, BL, Abou-Gharbia, MA, Raje, S, Parks, V, Pangalos, MN, Schechter, LE (2007). "Lecozotan Hydrochloride". Drugs of the Future 32 (5): 399–407. doi:10.1358/dof.2007.032.05.1092901.
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