• #LGM Pharma is a Ixabepilone CAS# 219989-84-1 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 219989-84-1
  • AHFC code:
  • Synonyms: Aza-epothilone B, Azaepothilone B, BMS-247550
  • ATC Code: L01DC04
  • Chemical Formula: C27H42N2O5
  • Molecular Weight: 506.698
  • Assay/Purity: Typically NLT 98%
  • DrugBank:
  • SMILES: C[C,H]1CCC[C,,]2(C)O[C,H]2C[C,H](NC(=O)C[C,,H](O)C(C)(C)C(=O)[C,,H](C)[C,H]1O)C(C)=CC1=CSC(C)=N1
  • PubChem: 6445540
  • IUPAC: (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14.1.0]heptadecane-8,12-dione

Additional Details

Investigated for use/treatment in breast cancer, head and neck cancer, melanoma, lung cancer, lymphoma (non-hodgkin’s), prostate cancer, renal cell carcinoma, and cancer/tumors (unspecified).
Mode of Action:
Binding of Ixabepilone to beta-tubulins (e.g. beta-III tubulin) stabilizes microtubules. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Like taxol, Ixabepilone binds to the αβ-tubulin heterodimer subunit. Once bound, the rate of αβ-tubulin dissociation decreases, thus stabilizing the microtubules.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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