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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 66108-95-0
  • AHFC code: 37:08.0
  • Synonyms: BRN 2406632, EC 266-164-2, EINECS 266-164-2, Exypaque, Iohexol, Iohexolum, Iohexolum [INN-Latin], N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide, Nycodenz, Omnipaque, Omnipaque 140, Omnipaque 180, Omnipaque 210, Omnipaque 240, Omnipaque 300, Omnipaque 350, Omnipaque 70, UNII-4419T9MX03, WIN 39424
  • ATC Code: V08AB02
  • Chemical Formula: C19-H26-I3-N3-O9
  • Molecular Weight: 821.126
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01362
  • SMILES: c1(N(C[C,,H](CO)O)C(C)=O)c(c(c(I)c(c1I)C(NC[C,,H](CO)O)=O)C(NC[C,,H](CO)O)=O)I
  • InChl: 1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)
  • PubChem:
  • IUPAC: 1,3-Benzenedicarboxamide, 5-(acetyl(2,3-dihydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-

Additional Details

Indication:
Iohexol ia used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures.
Pharmacodynamics:
Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Mode of Action:
Organic iodine compounds block x-rays as they pass through the body, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. After intrathecal administration into the subarachnoid space, diffusion of iohexol in the CSF allows the visualization of the subarachnoid spaces of the head and spinal canal. After intravascular administration, iohexol makes opaque those vessels in its path of flow, allowing visualization of the internal structures until significant hemodilution occurs.
Metabolism:
Toxicity:
Non-ionic radiocontrast agents like iohexol are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.
General Reference:
Kawada TK: Iohexol and iopamidol: second-generation nonionic radiographic contrast media. Drug Intell Clin Pharm. 1985 Jul-Aug;19(7-8):525-9. PubmedShaw DD, Potts DG: Toxicology of iohexol. Invest Radiol. 1985 Jan-Feb;20(1 Suppl):S10-3. Pubmed
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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