Ibudilast

CAS No:
50847-11-5 Category:
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 50847-11-5
  • AHFC code:
  • Synonyms: 2-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridine 3-isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine AV-411 Eyevinal I0157_SIGMA Ibudilast (jan/inn) Ibudilast [inn:jan] Ibudilastum Ibudilastum [latin] Ke tas Ketas Ketas (TN) Lopac-I-0157 MN-166 Pyrazolo(1,5-a)pyridine, 3-isobutyryl-2-isopropyl- Tocris-1694 UNII-M0TTH61XC5
  • ATC Code: R03DC04
  • Chemical Formula: C30H38O5
  • Molecular Weight: 230.3055
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB05266
  • SMILES: CC(C)C(=O)C1=C2C=CC=CN2N=C1C(C)C
  • InChl: ZJVFLBOZORBYFE-UHFFFAOYSA-N
  • PubChem: 3671
  • IUPAC: 2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one

Additional Details

Indication:
For the treatment of multiple sclerosis, asthma, and cerebrovascular disease.
Pharmacodynamics:
Mode of Action:
Ibudilast has mechanisms that include anti-inflammatory effects, such as phosphodiesterase inhibition, and neuroprotective effects, such as inhibition of [nitric oxide] synthesis and reduction in reactive oxygen species.
Metabolism:
Toxicity:
Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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