• #LGM Pharma is a Ibritumomab Tiuxetan CAS# 206181-63-7 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 206181-63-7
  • AHFC code:
  • Synonyms: BAY 86-5128, BAY86-5128, Ibritumomab, Ibritumomab tiuxetan, IDEC-129, IDEC-Y2B8, Immunoglobulin G1 (mouse monoclonal IDEC-Y2B8 gamma1-chain anti-human antigen CD20), disulfide with mouse monoclonal IDEC-Y2B8 K-chain, dimer, N-(2-(bis(carboxymethyl)amino)-3-(p-isothiocyanatophenyl)propyl)-N-(2-(bis(carboxymethyl)amino)propyl)glycine conjugate. Molecular weight is approximately 1500 daltons, SHL 749, UNII-4Q52C550XK, Zevalin
  • ATC Code:
  • Chemical Formula:
  • Molecular Weight: 570.5968
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00078
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC: Immunoglobulin G1, anti-(human CD20 (antigen)) (mouse monoclonal IDEC-Y2B8 gamma1-chain), disulfide with mouse monoclonal IDEC-Y2B8 kappa-chain, dimer, N-(2-(bis(carboxymethyl)amino)-3-(4-isothiocyanatophenyl)propyl)-N-(2-(bis(carboxymethyl)amino)propyl)glycine conjugate

Additional Details

Indication:
For treatment of non-Hodgkin’s lymphoma
Pharmacodynamics:
Ibritumomab is a murine monoclonal antibody against CD20 that has been radiolabeled with yttrium-90.
Mode of Action:
The Fab segment of the antibody targets the CD20 epitope on B-cells, allowing the radioactive yttrium to destroy the cell via production of beta particles.
Metabolism:
Most likely removed by opsonization via the reticuloendothelial system when bound to B cells, or by human antimurine antibody production
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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