Hydrochloride Sulfate

CAS No:
207671-44-1 Category:
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Product Details:

  • CAS No: 207671-44-1
  • AHFC code:
  • Synonyms: Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-, sulfate (2:1) (salt), dihydrate, Quinine sulfate, Quinine sulfate (2:1) (salt) dihydrate
  • ATC Code:
  • Chemical Formula: (C20-H24-N2-O2)2.H2-S-O4.2H2-O
  • Molecular Weight: 391.47
  • Assay/Purity: Typically NLT 98%
  • DrugBank:
  • SMILES: COc1ccc2c(c1)c(ccn2)[C,H]([C,,H]3CC4CCN3C[C,,H]4C=C)O.COc1ccc2c(c1)c(ccn2)[C,H]([C,,H]3CC4CCN3C[C,,H]4C=C)O.O.O.OS(=O)(=O)O
  • InChl: InChI=1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m00…/s1
  • PubChem:
  • IUPAC:

Additional Details

Indication:
Use to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites, the toxicity of heme (FP)-complexes and to inhibit mitochondrial ATP-regulated potassium channel.
Pharmacodynamics:
Mode of Action:
Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Metabolism:
Toxicity:
General Reference:
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