• #LGM Pharma is a Goserelin Acetate CAS# 145781-92-6 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 145781-92-6
  • AHFC code: 68:18.00, 92:00.00
  • Synonyms:
  • ATC Code: L02AE03
  • Chemical Formula: C59-H84-N18-O14.x-C2-H4-O2
  • Molecular Weight: 1329.4762
  • Assay/Purity: Typically NLT 98%
  • DrugBank: BTD00113
  • SMILES: CC(C)C[C,,H](C(=O)N[C,,H](CCCNC(=N)N)C(=O)N1CCC[C,H]1C(=O)NNC(=O)N)NC(=O)[C,,H](COC(C)(C)C)NC(=O)[C,H](Cc2ccc(cc2)O)NC(=O)[C,H](CO)NC(=O)[C,H](Cc3c[nH]c4c3cccc4)NC(=O)[C,H](Cc5c[nH]cn5)NC(=O)[C,,H]6CCC(=O)N6.CC(=O)O
  • InChl:
  • PubChem: 5311128
  • IUPAC: 1-9-Luteinizing hormone-releasing factor (swine), 6-(O-(1,1-dimethylethyl)-D-serine)-, 2-(aminocarbonyl)hydrazide, acetate (salt)

Additional Details

Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty.
The pharmacokinetics of goserelin have been determined in both male and female healthy volunteers and patients. In these studies, goserelin was administered as a single 250µg (aqueous solution) dose and as a single or multiple 3.6 mg depot dose by subcutaneous route.
Mode of Action:
Goserelin is a synthetic decapeptide analogue of LHRH. Goserelin acts as a potent inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation. The result is sustained suppression of LH and serum testosterone levels.
No experience of overdosage from clinical trials.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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