• #LGM Pharma is a Glucarpidase CAS# 9074-87-7 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 9074-87-7
  • AHFC code:
  • Synonyms: Carboxypeptidase G2
  • ATC Code: V03AF09
  • Chemical Formula: C1950H3157N543O599S7
  • Molecular Weight: 44016.6653 g/mol
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB08898
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC:

Additional Details

Indication:
Used in patients on methotrexate treatment who have kidney dysfunction, and are experiencing an abnormally high plasma concentration of methotrexate (> 1 micromole per liter).
Pharmacodynamics:
Glucarpidase acts as an antidote to toxic methotrexate levels by elminating methotrexate by a non-kidney route.
Mode of Action:
Glucarpidase inactivates methotrexate, and other antifolates, by hydrolyzing glutamate on the carboxyl terminal of these compounds. For methotrexate specifically, it is hydrolyzed to the inactive metabolites glutamate and 4-deoxy-4-amino-N10-methylpteroic acid (DAMPA).
Metabolism:
Metabolism was not determined.
Toxicity:
Most common adverse reactions include hypotension, flushing, nausea, vomiting, headache, and paresthesia.
General Reference:
Green JM: Glucarpidase to combat toxic levels of methotrexate in patients. Ther Clin Risk Manag. 2012;8:403-13. doi: 10.2147/TCRM.S30135. Epub 2012 Nov 22. Pubmed Tuffaha HW, Al Omar S: Glucarpidase for the treatment of life-threatening methotrexate overdose. Drugs Today (Barc). 2012 Nov;48(11):705-11. doi: 10.1358/dot.2012.48.11.1871575. Pubmed FDA label.
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