Flutamide

CAS No:
13311-84-7 Category:
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Product Details:

  • CAS No: 13311-84-7
  • AHFC code: 10:00.0
  • Synonyms: Flutamide USP25
  • ATC Code: L02BB01
  • Chemical Formula: C32H47F5O3S
  • Molecular Weight: 276.2118
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00499 (APRD00984)
  • SMILES: CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F
  • InChl: MKXKFYHWDHIYRV-UHFFFAOYSA-N
  • PubChem: 3397
  • IUPAC: 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

Additional Details

Indication:
For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
Pharmacodynamics:
Flutamide is a nonsteroidal antiandrogen. In animal studies, flutamide demonstrates potent antiandrogenic effects. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or both. Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g. castration. Elevations of plasma testosterone and estradiol levels have been noted following flutamide administration.
Mode of Action:
Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen.
Metabolism:
Flutamide is rapidly and extensively metabolized, with flutamide comprising only 2.5% of plasma radioactivity 1 hour after administration.
Toxicity:
In animal studies with flutamide alone, signs of overdose included hypoactivity, piloerection, slow respiration, ataxia, and/or lacrimation, anorexia, tranquilization, emesis, and methemoglobinemia.
General Reference:
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