Flumethasone Pivalate

2002-29-1 Category:
  • #LGM Pharma is a Flumethasone Pivalate CAS# 2002-29-1 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 2002-29-1
  • AHFC code:
  • Synonyms:
  • ATC Code: C05AA10 D07AC04
  • Chemical Formula: C21H23ClFN3O
  • Molecular Weight: 494.5679
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00663 (APRD00975)
  • SMILES: C[C,,H]1C[C,H]2[C,,H]3C[C,H](F)C4=CC(=O)C=C[C,]4(C)[C,,]3(F)[C,,H](O)C[C,]2(C)[C,,]1(O)C(=O)COC(=O)C(C)(C)C
  • PubChem:
  • IUPAC: 2-[(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl 2,2-dimethylpropanoate

Additional Details

For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions
Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
Mode of Action:
Flumethasone is a glucocorticoid receptor agonist. This complex binds to the nucleus causing a variety of genetic activation and repressions. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.
Primarily hepatic
Can lead to signs of irritation such as burning sensation, itching or skin rash at the site of application; hypersensitivity reactions.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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