286930-03-8 Category:
  • #LGM Pharma is a Fesoterodine CAS# 286930-03-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 286930-03-8
  • AHFC code: 12:08.1
  • Synonyms:
  • ATC Code: G04BD11
  • Chemical Formula: C4H4FN3O
  • Molecular Weight: 411.5769
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB06702
  • PubChem: 6918558
  • IUPAC: 2-[(1R)-3-[bis(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate

Additional Details

For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
Fesoterodine is a prodrug. In vivo it is broken down into its active metabolite, 5-hydroxymethyl tolterodine, by plasma esterases. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Therefore, acting as a competitive muscarinic receptor antagonist, fesoterodine ultimately acts to decrease the detrusor pressure by its muscarinic antagonism, thereby decreasing bladder contraction and consequently, the urge to urinate.
Mode of Action:
Fesoterodine, once converted to its active metabolite, 5-hydroxymethyltolterodine, acts as a competitive antagonists at muscarinic receptors. This results in the inhibition of bladder contraction, decrease in detrusor pressure, and an incomplete emptying of the bladder.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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