Ferric Carboxymaltose

CAS No:
9007-72-1 Categories: , ,
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Product Details:

  • CAS No: 9007-72-1
  • AHFC code: 20:04.0
  • Synonyms: Ferinject Ferric carboxymaltose Injectafer Iron Dextri-Maltose Polynuclear iron (III)-hydroxide 4(R)-(poly-(1->4)-O-alpha-D-glucopyranosyl)-oxy- 2(R),3(S),5(R), 6-tetrahydroxy-hexanoate UNII-6897GXD6OE VIT 45 VIT-45
  • ATC Code:
  • Chemical Formula:
  • Molecular Weight: 788.4316
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB08917
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC: Iron(3+) hydroxide oxide poly-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-gluconate hydrate

Additional Details

Indication:
Ferric carboxymaltose is a iron replacement product indicated for the treatment of iron deficiency anemia in adult patients who have intolerance to oral iron or have had unsatisfactory response to oral iron or those who have non-dialysis dependent chronic kidney disease.
Pharmacodynamics:
When measured using positron emission tomography (PET), the red cell uptake of 59-Fe and 52-Fe from INJECTAFER ranged from 61% to 99%. In patients with iron deficiency, the red cell uptake ranged from 91% to 99%. In patients with renal anemia, the red cell uptake ranged from 61% to 84%.
Mode of Action:
Ferric carboxymaltose is a colloidal iron (III) hydroxide in complex with carboxymaltose, a carbohydrate polymer that release iron.
Metabolism:
Toxicity:
The most common adverse reactions (>2%) are nausea, hypertension, flushing, hypophosphatemia, and dizziness.
General Reference:
FDA label
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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